IDARUBICIN HYDROCHLORIDE

Synonyms. Idarubicin hydrochloride; DMDR; IMI-30; (1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12- trihydroxy- 6,11-dioxo-1- naphthacenyl  3-amino-2,3,6-trideoxy-alpha-L- lyxo-hexopyranoside hydrochloride; Idamycin; (7S-cis)-9-Acetyl-7-((3-Amino-2,3,6- trideoxy-alpha-L-lyxo-hexopyranosyl)oxy) -7,8,9,10- tetrahydro-6,9,11-trihydroxy- 5,12-naphthacenedione; 4-Demethoxydaunorubicin hydrochloride; Idamycin; Zavedos;

IDARUBICIN HCl

 

PRODUCT IDENTIFICATION

CAS RN

57852-57-0 (hydrochloride), 58957-92-9 (parent)

EINECS RN

260-990-7

FORMULA

 C26H27NO9·HCl

MOLE WEIGHT

533.95

H.S CODE

 2932.99.9090

SMILES

 c12c(c(c3C(c4ccccc4C(c3c2O)=O)=O)O)C[C@](C(C)=O)(O)C [C@@H]1O [C@@H ]1C[C@@H]([C@@H](O)[C@@H](O1)C)N.Cl

CLASSIFICATION

Antineoplastic, Antibiotic, Anthracycline, Topoisomerase II Inhibitor

EXTRA NOTES

 An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

yellow to red crystalline powder

MELTING POINT

183 ~ 185 C (Decomposes)

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

Slightly soluble.

SOLVENT SOLUBILITY  

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 
STABILITY AND REACTIVITY
STABILITY Stable under normal conditions. Hygroscopic and light sensitive

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 3,Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Idarubicin

Google Scholar Search - Idarubicin

Drug Information Portal (U.S. National Library of Medicine) - Idarubicin

PubChem Compound Summary - Idarubicin

Drug Bank -  Idarubicin

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Idarubicin

http://www.ebi.ac.uk/ - Idarubicin

http://www.ncbi.nlm.nih.gov/ - Idarubicin

http://www.epharmacognosy.com/
Characteristic Features Idarubicin Hydrochloride: [C26H27NO9.HCl] [Synonyms: Idamycin, Zavedos]: It is obtained as orange crystalline powder having mp 183-185°C. It has specific optical rotation [α]D20 + 205° (C = 0.1 in methanol). Uses - 1. It is mostly used as an antineoplastic agent. 2. It may show increased activity with comparatively much lesser cardiotoxicity. Note: The major drawback of structurally related and modified semi-synthetic doxorubicintype antibiotic is due to their significant cardiotoxicity that invariably comes into being by virtue of the distinct inhibition of cardiac Na+, K+-ATpase.

 

SALES SPECIFICATION

APPEARANCE

 yellow to red crystalline powder

IDENTIFICATION

positive (Test A,B)

ASSAY

97.5 - 100.5%
RELATED MATTERS

2.0% max
SPECIFIC ROTATION

+203° ~ +207° (c = 0.1 in MeOH)

HEAVY METALS

20ppm max
pH

5 ~ 6.5
RESIDUE ON IGNITION

0.1% max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

2811

HAZARD CLASS

 6.1
PACKING GROUP II

 

SAFETY INFORMATION

HAZARD OVERVIEW

Target Organ Effect, Highly toxic by ingestion, Teratogen, Reproductive hazard, Mutagen. Target Organs: Kidney, Heart, Blood, Gastrointestinal tract, Testes. Fatal if swallowed. Suspected of causing cancer. May damage fertility or the unborn child.

GHS

  

SIGNAL WORD

Danger

PICTOGRAMS

HAZARD STATEMENTS

H300-H351-H360

P STATEMENTS

P201-P264-P281-P301 + P310-P308 + P313

EC DIRECTIVES

 

HAZARD CODES

T+: Very Toxic

RISK PHRASES

60-61-28-40

SAFETY PHRASES

 45-53

 

PACKING